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Related Concept Videos

Schizophrenia01:17

Schizophrenia

170
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
170
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

152
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
152
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

788
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
788
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

371
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
371
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

109
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
109
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

173
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
173

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Updated: Aug 2, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Approach to schizophrenia.

Anthony Harris1,2,3

  • 1Specialty of Psychiatry, Sydney Medical School, Faculty of Medicine and Health Sciences, University of Sydney, Sydney, New South Wales, Australia.

Internal Medicine Journal
|April 18, 2023
PubMed
Summary
This summary is machine-generated.

Schizophrenia, a common psychotic disorder with genetic roots, presents diverse symptoms and functional decline. While early intervention helps immediate outcomes, long-term results for schizophrenia patients remain unchanged.

Keywords:
physical healthpsychosisschizophreniatreatment

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Genetics

Background:

  • Schizophrenia is a prevalent psychotic disorder affecting approximately 3% of the population.
  • It has identifiable genetic antecedents, influenced by biological and social factors.
  • Diagnosis involves characteristic symptoms (positive, negative, disorganization, cognitive, affective) and functional decline.

Purpose of the Study:

  • To review the multifaceted nature of schizophrenia.
  • To highlight diagnostic criteria and the role of investigations.
  • To discuss current treatment paradigms and patient outcomes.

Main Methods:

  • Literature review of schizophrenia's genetic, biological, and social aspects.
  • Analysis of diagnostic criteria and symptom presentation.
  • Examination of treatment modalities and patient health outcomes.

Main Results:

  • Schizophrenia exhibits clear genetic links but is modulated by various factors.
  • Investigations exclude organic causes and establish treatment baselines.
  • Physical health is often poor due to inconsistent healthcare.

Conclusions:

  • Treatment combines pharmacological and psychosocial interventions.
  • Earlier intervention improves short-term outcomes but not long-term prognosis.
  • Integrated care is crucial for improving the overall health and outcomes of individuals with schizophrenia.