Immune activity of Ki-67 during nasal polyp development

Area of Science:

• Otorhinolaryngology
• Pathology
• Immunohistochemistry

Background:

• Nasal polyps are benign growths of the nasal mucosa.
• Understanding the cellular mechanisms and markers in nasal polyps is crucial for diagnosis and management.

Purpose of the Study:

• To investigate the expression level of Ki-67 in nasal polyps using immunohistochemical methods.
• To explore the potential diagnostic value of Ki-67 in nasal polyp tissues.

Main Methods:

• The study included 30 patients diagnosed with nasal polyps.
• Nasal polyp samples underwent standard paraffin embedding, fixation, and sectioning.
• Immunohistochemical staining with Ki-67 antibody was performed, followed by light microscopy analysis.

Main Results:

• Blood analysis revealed elevated white blood cells, hematocrit, and platelets.
• Histopathological examination showed basal cell hyperplasia, thin basement membrane, leukocyte infiltration, and collagen degeneration.
• Ki-67 expression was detected in mucosal epithelial cells, vascular endothelial cells, and plasma cells.

Conclusions:

• Epithelial changes and leukocyte infiltration in nasal polyps may contribute to nasal adenoma formation.
• Ki-67 expression presents a potential diagnostic tool for identifying epithelial leukocyte formation in nasal polyps.