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Related Experiment Video

Updated: Aug 2, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Precision immunotherapy treatment for sepsis.

J Wang¹, G Zhang

¹Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 3204091@zju.edu.cn.

European Review for Medical and Pharmacological Sciences

|April 18, 2023

Summary

Sepsis immunotherapy research is advancing, focusing on immune disorders beyond initial inflammation. Understanding the immune microenvironment is crucial for developing effective treatments and improving patient outcomes in intensive care units.

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Last Updated: Aug 2, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Published on: June 15, 2019

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

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Published on: April 11, 2012

Cecal Ligation Puncture Procedure

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Published on: May 7, 2011

Area of Science:

Critical care medicine
Immunology
Infectious diseases

Background:

Sepsis is a leading cause of mortality and healthcare costs in intensive care units.
Current understanding of sepsis extends beyond initial inflammation to include immune dysregulation.
Immune disorders contribute to persistent infection, secondary infections, and organ dysfunction in sepsis.

Purpose of the Study:

To provide a comprehensive analysis of sepsis immunotherapy.
To explore immune status evaluation in sepsis.
To discuss potential immunotherapy drugs, challenges, and future research directions.

Main Methods:

Literature review and analysis of current research on sepsis immunotherapy.
Examination of immunological aspects of sepsis.
Discussion of clinical implications and future prospects.

Main Results:

Sepsis immunotherapy is an active research area with no fully approved clinical drugs.
Understanding the immunological microenvironment in sepsis is incomplete.
Significant challenges exist in developing effective sepsis immunotherapies.

Conclusions:

Further research into sepsis immunotherapy is essential.
A deeper understanding of the immune microenvironment is needed for therapeutic advancements.
This review aims to guide future clinical practice and research in sepsis immunotherapy.