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Aztreonam penetration into synovial fluid and bone
Antimicrobial Agents and Chemotherapy
|April 1, 1986
Summary
Aztreonam, an antibiotic, reaches high concentrations in joint fluid and bone tissue after a single intravenous dose before surgery. This suggests effective antibiotic levels for preventing infection in patients undergoing joint replacement surgery.
Area of Science:
- Pharmacology
- Orthopedic Surgery
- Infectious Disease
Background:
- Degenerative joint disease often necessitates joint replacement surgery.
- Surgical site infections are a significant complication in joint replacement procedures.
- Antibiotic prophylaxis is crucial for preventing infections during orthopedic surgery.
Purpose of the Study:
- To determine the concentration of aztreonam in synovial fluid and cancellous bone following preoperative intravenous administration.
- To assess the penetration of aztreonam into target tissues relevant to joint replacement surgery.
Main Methods:
- Eighteen patients with degenerative joint disease undergoing hip or knee replacement were administered a single 2-g intravenous dose of aztreonam preoperatively.
- Synovial fluid and cancellous bone samples were collected during surgery.
- Aztreonam concentrations in synovial fluid and bone were measured and compared to serum levels.
Main Results:
- Mean aztreonam concentration in synovial fluid was 83.0 +/- 9.2 micrograms/ml, approximately 0.99 times serum levels.
- Mean aztreonam concentration in cancellous bone was 16.0 +/- 4.3 micrograms/g, approximately 0.20 times serum levels.
Conclusions:
- Intravenous aztreonam achieves substantial concentrations in synovial fluid and bone tissue in patients undergoing joint replacement.
- These findings support the use of aztreonam for surgical prophylaxis in patients with degenerative joint disease requiring hip or knee replacement.
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