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Chemical Zymogens: Specificity and Steroidal Control of Reactivation

Mireia Casanovas Montasell1, Anna Baumann1, Alexander N Zelikin1

  • 1Department of Chemistry and, iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark.

Chembiochem : a European Journal of Chemical Biology
|April 18, 2023
PubMed
Summary

This study introduces specific reactivation of synthetic chemical zymogens by engineering activator affinity and using steroidal hormones for controlled enzyme activation, advancing chemical biology tools.

Keywords:
Covalent protein modificationCysteinomeEnzyme activationEnzyme chemistry

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