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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Does asthma-bronchiectasis overlap syndrome (ABOS) really exist?

Angelica Tiotiu1,2, Miguel-Angel Martinez-Garcia3,4, Paula Mendez-Brea5

  • 1Department of Pulmonology, University Hospital of Nancy, Nancy, France.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|April 18, 2023
PubMed
Summary
This summary is machine-generated.

The asthma-bronchiectasis phenotype likely exists, with bronchiectasis being more common in asthma patients. Shared mechanisms and comorbidities contribute, but definitive causal proof requires more research.

Keywords:
Asthmabronchiectasiscomorbiditieseosinophilsexacerbationoverlapprognosis

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Area of Science:

  • Respiratory Medicine
  • Pulmonology
  • Clinical Immunology

Background:

  • Asthma and bronchiectasis are distinct respiratory conditions.
  • The co-occurrence of these conditions presents diagnostic and therapeutic challenges.
  • A specific asthma-bronchiectasis phenotype is increasingly recognized.

Purpose of the Study:

  • To investigate the relationship between asthma and bronchiectasis.
  • To define the criteria for an asthma-bronchiectasis phenotype.
  • To explore shared etiopathogenic mechanisms and comorbidities.

Main Methods:

  • Systematic literature search of PubMed using "asthma" and "bronchiectasis" keywords.
  • Inclusion of clinical trials, meta-analyses, RCTs, cohort studies, and systematic reviews.
  • Focus on adult patients with studies published up to November 2022.

Main Results:

  • Bronchiectasis prevalence is elevated in asthma patients, especially severe cases.
  • Asthma may cause bronchiectasis in 1.4%-7% of patients.
  • Shared mechanisms include inflammation, microbiota alterations, and immune dysfunction.
  • Comorbidities like GERD and psychiatric illnesses are common.

Conclusions:

  • Evidence supports the existence of an asthma-bronchiectasis phenotype.
  • Shared pathophysiological pathways and clinical presentations are evident.
  • Further longitudinal studies are needed to confirm asthma as a direct cause of bronchiectasis.