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[Phase II study of decarbazine (DTIC) in malignant melanoma. DTIC Research Group]
Abstract:
A phase II study of DTIC was carried out with a response rate (CR and PR) of 24.2%. Metastases to liver, lymph nodes and subcutaneous tissues were susceptible to the drug. Most of the adverse reactions observed were upper gastrointestinal symptoms such as nausea in 15.4%, vomiting in 5.8% and anorexia in 3.8%. Alterations in white blood cells, red blood cells or platelets exceeding Grade 2 were not observed. As for biochemistry, GOT was increased in 25.0% and GPT in 28.2%. However, these were mild and transient changes, disappearing in 3 to 4 weeks. The results seem to reproduce those of various U.S. group studies.
Insights
Dacarbazine (DTIC) showed a 24.2% response rate in a phase II study, effectively treating liver, lymph node, and subcutaneous metastases. Adverse effects were primarily mild gastrointestinal issues, with no significant hematologic toxicity observed.
Area of Science:
- Medical Oncology
- Clinical Pharmacology