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Executive function, behavioral problems, and insulin resistance in adolescents with obesity
Ummugulsum Gundogdu1, Guliz Gurer2, Mehtap Eroglu3
1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Marmara University, Istanbul, Türkiye.
Journal of Pediatric Endocrinology & Metabolism : JPEM
|April 18, 2023
Summary
Adolescents with obesity experience more executive function deficits, behavioral issues, and lower quality of life. Insulin resistance is linked to poorer quality of life but not executive function or behavioral problems in this group.
Area of Science:
- Pediatric Endocrinology
- Adolescent Health
- Metabolic Syndrome
Background:
- Obesity in adolescents is a growing concern with potential impacts on cognitive and emotional well-being.
- Executive function (EF), behavioral and emotional (BE) issues, and quality of life (QoL) are crucial aspects of adolescent development.
- Insulin resistance (IR) is a common comorbidity in adolescent obesity, but its specific associations with EF, BE, and QoL are not fully understood.
Purpose of the Study:
- To compare executive function (EF) abilities, behavioral and emotional (BE) issues, and quality of life (QoL) between adolescents with and without obesity.
- To investigate the association between insulin resistance (IR) and EF, BE issues, and QoL in adolescents with obesity.
Main Methods:
- Cross-sectional study of 100 adolescents (50 with obesity, 50 normal weight), aged 11-18 years.
- Data collection included sociodemographic interviews, anthropometric measurements, and biochemical assessments (fasting blood glucose, insulin).
- Standardized questionnaires (Kiddo-KINDL, Strengths and Difficulties Questionnaire, Behavior Rating Inventory of Executive Function) assessed QoL, BE issues, and EF.
Main Results:
- Adolescents with obesity exhibited more EF deficiencies, BE difficulties, peer relationship problems, and lower QoL compared to controls.
- Poorer QoL was observed in girls, adolescents with obesity, and those with IR.
- No significant differences in EF deficiencies or BE problems were found between adolescents with obesity with or without IR.
Conclusions:
- Adolescents with obesity face significant challenges in executive function, behavior, and quality of life.
- Interventions targeting EF deficits and BE problems are essential for improving lifestyle adaptation and treatment success in pediatric obesity.
- The presence of insulin resistance negatively impacts quality of life in obese adolescents.
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