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Related Experiment Video

Updated: Aug 2, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Biodegradable Microneedles Array with Dual-Release Behavior and Parameter Optimization by Finite Element Analysis.

Shuai Xu1, Wenyuan Liu1, Mingwei Peng1

  • 1Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, Suqian Advanced Materials Industry Technology Innovation Center, NJTech-BARTY Joint Research Center for Innovative Medical Technology, Nanjing Tech University, Nanjing, China.

Journal of Pharmaceutical Sciences
|April 18, 2023
PubMed
Summary

This study introduces a novel biodegradable microneedle (MNs) array made from silk fibroin and poly(vinyl alcohol) for enhanced transdermal drug delivery. The new MNs offer improved mechanical strength and a dual-release profile for effective and sustained therapeutic compound delivery.

Keywords:
Finite element analysisHybrid materialMicroneedleSilk fibroinTransdermal delivery

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Microneedles (MNs) offer advantages for transdermal drug delivery, including enhanced safety and patient compliance.
  • Existing dissolving MNs lack mechanical strength and sustainability, while hydrogel MNs present fabrication and safety challenges.

Purpose of the Study:

  • To develop a biodegradable microneedle (MNs) array using silk fibroin and poly(vinyl alcohol) to overcome limitations of current MN technologies.
  • To optimize MN fabrication parameters using finite element analysis for effective transdermal delivery.

Main Methods:

  • Fabrication of a biodegradable microneedle (MNs) array using silk fibroin and poly(vinyl alcohol).
  • Finite element analysis for optimizing MN design parameters.
  • Mechanical testing to assess stratum corneum penetration capability.
  • In vitro drug release studies to characterize release kinetics.

Main Results:

  • The optimized MNs array demonstrated sufficient mechanical strength to breach the stratum corneum, creating microchannels for drug delivery.
  • A dual-release profile was observed, featuring an initial rapid release followed by sustained release, fitting the Weibull model.
  • The MNs array is easily fabricated, mechanically robust, and addresses safety concerns associated with other MN types.

Conclusions:

  • The developed biodegradable silk fibroin and poly(vinyl alcohol) microneedle array offers a promising platform for transdermal drug delivery.
  • The dual-release characteristic is advantageous for topical applications, enabling rapid therapeutic onset and prolonged drug exposure.
  • This MNs array technology is scalable, cost-effective, and overcomes key limitations of existing microneedle systems.