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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients
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Short-term Trajectories of Poststroke Cognitive Function: A STROKOG Collaboration Study.

Jessica W Lo1, John D Crawford2, David W Desmond2

  • 1From the Centre for Healthy Brain Ageing (CHeBA) (J.W.L., J.D.C., H.B., D.M.L., B.C.P.L., P.S.S.), UNSW, Sydney, Australia; No affiliation (D.W.D.); Department of Neurology (H.-J.B.), Seoul National University School of Medicine, Seoul National University Bundang Hospital, Seongnam; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Neurology and Laboratory of Functional Neurosciences (O.G., M.R.), University Hospital of Amiens, France; Department of Psychiatry and Neuropsychology (S.K., F.V.), School for Mental Health and Neuroscience (MHeNs), Alzheimer Center Limburg, Maastricht University; Department of Neurology (J.S.), School for Cardiovascular diseases (CARIM), Maastricht University Medical Center (MUMC+), the Netherlands; Memory Aging and Cognition Centre (C.C., X.X., E.J.C.), Departments of Pharmacology and Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore; The Second Affiliated Hospital and School of Public Health (X.X.), Zhejiang University School of Medicine, Hangzhou, China; National Neuroscience Institute (N.K.); Duke-NUS Medical School (N.K.), Singapore; University of Lille (R.B., T.D., A.-M.M.), Inserm, CHU de Lille, Lille Neuroscience and Cognition, France; Dementia Collaborative Research Centre (H.B., P.S.S.), UNSW Medicine, UNSW, Sydney, Australia; Clinic of Neurology (L.T., S.M.), UH "Alexandrovska," Medical University-Sofia; and Kaneff University Hospital (N.P.), Ruse, Bulgaria. jessica.lo@unsw.edu.au.

Neurology
|April 18, 2023
PubMed
Summary
This summary is machine-generated.

Poststroke cognitive function trajectories vary significantly. Baseline cognition approximately 3.6 months after stroke predicts long-term outcomes, with older age, less education, and diabetes being risk factors for poorer cognitive performance.

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Psychology

Background:

  • Previous research on poststroke cognitive function primarily examined average performance or changes over time.
  • Few studies have investigated distinct patterns or trajectories of cognitive function in the first year after stroke.

Conclusions:

  • Cognitive function trajectories in the first year poststroke are heterogeneous.
  • Baseline cognitive function around 3.6 months poststroke is a strong predictor of long-term cognitive outcomes.
  • Older age, lower education, diabetes, large artery stroke type, and higher stroke severity are risk factors associated with poorer cognitive trajectories.