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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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News in diagnostics and treament of cardiomyopathies

Hana Poloczková, Tomáš Honek, Anna Chaloupka

    Vnitrni Lekarstvi
    |April 18, 2023
    PubMed

    Insights

    Cardiomyopathies are heart muscle diseases affecting structure and function. Early detection and treatment are crucial for improving outcomes in affected individuals, particularly young people.

    Area of Science:

    • Cardiology
    • Internal Medicine
    • Genetics

    Background:

    • Cardiomyopathies are myocardial disorders characterized by structural and functional abnormalities.
    • They are distinct from heart conditions caused by other diseases like hypertension or coronary artery disease.
    • Phenotypic expression can vary and evolve, encompassing familial and acquired forms.

    Purpose of the Study:

    • To define and classify cardiomyopathies based on phenotype.
    • To outline the diverse clinical manifestations and etiological factors.
    • To highlight the importance of early diagnosis and treatment.

    Main Methods:

    • Phenotypic classification of cardiomyopathies (dilated, hypertrophic, restrictive, arrhythmogenic, unclassified).
    • Distinguishing between familial (genetic) and acquired forms.
    • Clinical assessment of symptoms including heart failure and arrhythmias.

    Main Results:

    • Cardiomyopathies present with varied symptoms of heart failure and arrhythmias, sometimes with delayed onset.
    • The disease can lead to significant morbidity and mortality, especially in younger populations.
    • Recent advancements in diagnostics and therapeutics have improved patient prognosis.

    Conclusions:

    • Cardiomyopathies represent a heterogeneous group of heart muscle diseases requiring careful classification.
    • Early identification and intervention are critical for managing morbidity and mortality.
    • Ongoing developments in diagnosis and treatment offer improved outlooks for patients.

    Keywords:
    SGLT2cardiac magnetic resonancecardiomyopathygenetic testingheart failuremagnetic resonance

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