Related Experiment Video
Updated: Aug 2, 2025
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
1.6K
Emerging roles of non-coding RNAs in psoriasis pathogenesis
Debakreeta Ghosh1, Torsa Ganguly1, Raghunath Chatterjee2
1Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata, 700 108, India.
Functional & Integrative Genomics
|April 18, 2023
Summary
Non-coding RNAs (ncRNAs) play a crucial role in the development of psoriasis, a chronic skin condition. Further research into ncRNAs like microRNAs, long noncoding RNAs, and circular RNAs is needed to understand their function in psoriasis pathogenesis.
Area of Science:
- Dermatology
- Molecular Biology
- Epigenetics
Background:
- Psoriasis is a chronic genetic skin disorder characterized by inflammatory plaques.
- Current treatments manage symptoms, but a permanent cure is lacking.
- While genetic factors are known, the epigenetic basis of psoriasis is not fully understood.
Purpose of the Study:
- To review the molecular mechanisms of non-coding RNAs (ncRNAs) in psoriasis pathogenesis.
- To highlight the established roles of microRNAs (miRNAs) and emerging roles of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs).
- To identify areas requiring further scientific investigation.
Main Methods:
- Literature review of scientific studies on ncRNAs and psoriasis.
- Analysis of documented functions of various ncRNAs in disease development.
- Synthesis of current findings and identification of research gaps.
Main Results:
- ncRNAs are key regulators of epigenetic processes involved in psoriasis.
- miRNAs are well-studied, while lncRNAs and circRNAs show emerging roles.
- Diverse ncRNAs influence keratinocyte proliferation, differentiation, and immune cell infiltration.
Conclusions:
- ncRNAs are integral to psoriasis pathogenesis, offering potential therapeutic targets.
- Further research is essential to elucidate the complex roles of lncRNAs and circRNAs.
- Understanding ncRNA functions can lead to improved psoriasis management strategies.
More Related Videos
Related Concept Videos
01:24T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
02:39lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
01:20Types of RNA
5.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.9K
01:20The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
02:57piRNA - Piwi-interacting RNAs
6.9K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
6.9K
01:21EPS and iPS Cells in Disease Research
2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K