Related Experiment Video
Updated: Aug 2, 2025
07:41
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
2.5K
The "Great Debate" at Melanoma Bridge 2022, Naples, December 1st-3rd, 2022
Paolo A Ascierto1, Christian Blank2, Alexander M Eggermont3,4
1Department of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.
Journal of Translational Medicine
|April 18, 2023
Summary
Experts debated key melanoma management strategies, including anti-lymphocyte-activation gene (LAG)-3 vs. ipilimumab with anti-programmed death (PD)-1 therapy and the role of adjuvant treatments. Audience votes reflected the dynamic discussions on these critical topics.
Area of Science:
- Oncology
- Immunotherapy
- Surgical Oncology
Background:
- The 2022 Melanoma Bridge congress hosted a Great Debate session.
- Leading experts presented counterpoint views on contemporary melanoma management challenges.
Purpose of the Study:
- To explore and debate pivotal issues in melanoma treatment.
- To gauge expert and audience perspectives on controversial topics in melanoma care.
Main Methods:
- Five key debate topics were addressed by invited speakers.
- Expert opinions were presented on specific treatment choices and strategies.
- Audience voting was conducted before and after each debate to assess opinion shifts.
Main Results:
- Debates covered anti-lymphocyte-activation gene (LAG)-3 therapy versus ipilimumab in combination with anti-programmed death (PD)-1 therapy.
- Discussions addressed the acceptability of anti-PD-1 monotherapy as a clinical trial comparator.
- The utility of adjuvant treatment and its specific role in stage II melanoma were debated.
- The evolving role of surgery in melanoma management was also a key discussion point.
Conclusions:
- The debates highlighted ongoing controversies and evolving expert opinions in melanoma management.
- Audience engagement through voting underscored the dynamic nature of these clinical discussions.
Related Concept Videos
01:30Skin Cancer
4.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.3K
01:30Cancer Vaccines
456
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
456
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:27Tumor Immunotherapy
596
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
596
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K