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The "Great Debate" at Melanoma Bridge 2022, Naples, December 1st-3rd, 2022

Paolo A Ascierto1, Christian Blank2, Alexander M Eggermont3,4

  • 1Department of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.

Journal of Translational Medicine
|April 18, 2023
PubMed

Insights

Experts debated key melanoma management strategies, including anti-lymphocyte-activation gene (LAG)-3 vs. ipilimumab with anti-programmed death (PD)-1 therapy and the role of adjuvant treatments. Audience votes reflected the dynamic discussions on these critical topics.

Area of Science:

  • Oncology
  • Immunotherapy
  • Surgical Oncology

Background:

  • The 2022 Melanoma Bridge congress hosted a Great Debate session.
  • Leading experts presented counterpoint views on contemporary melanoma management challenges.

Purpose of the Study:

  • To explore and debate pivotal issues in melanoma treatment.
  • To gauge expert and audience perspectives on controversial topics in melanoma care.

Main Methods:

  • Five key debate topics were addressed by invited speakers.
  • Expert opinions were presented on specific treatment choices and strategies.
  • Audience voting was conducted before and after each debate to assess opinion shifts.

Main Results:

  • Debates covered anti-lymphocyte-activation gene (LAG)-3 therapy versus ipilimumab in combination with anti-programmed death (PD)-1 therapy.
  • Discussions addressed the acceptability of anti-PD-1 monotherapy as a clinical trial comparator.
  • The utility of adjuvant treatment and its specific role in stage II melanoma were debated.
  • The evolving role of surgery in melanoma management was also a key discussion point.

Conclusions:

  • The debates highlighted ongoing controversies and evolving expert opinions in melanoma management.
  • Audience engagement through voting underscored the dynamic nature of these clinical discussions.
Keywords:
AdjuvantAnti-PD-1ImmunotherapyMelanomaNeoadjuvantSurgeryTargeted therapy

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