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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Association between axial length and HDL in children: a hospital-based cross-sectional study
Qingqing Zheng1, Chaoyang Hong1, Yaling Peng2
1Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Insights
Children with longer axial lengths tend to have lower high-density lipoprotein (HDL) cholesterol levels. This study found a significant inverse relationship between eye axial length and HDL in pediatric participants.
Area of Science:
- Ophthalmology
- Pediatric Health
- Biochemistry
Background:
- Childhood eye growth and development are influenced by various factors.
- Cholesterol levels, particularly high-density lipoprotein (HDL), play a role in overall health.
- Understanding the interplay between ocular parameters and metabolic markers in children is crucial.
Purpose of the Study:
- To investigate the association between axial length of the eye and serum high-density lipoprotein (HDL) cholesterol levels in a pediatric cohort.
- To determine if a correlation exists between ocular biometry and lipid profiles in children.
Main Methods:
- A retrospective, cross-sectional study involving 69 children who underwent health examinations.
- Participants were categorized into three groups based on axial length: <=23 mm, 23-24 mm, and >24 mm.
- Ophthalmic measurements, including axial length, and blood biochemical parameters, specifically HDL levels, were analyzed.
Main Results:
- A statistically significant inverse correlation (R = -0.43, p = 0.00025) was observed between axial length and HDL levels.
- Mean HDL levels differed significantly across the three axial length groups.
- Children with longer axial lengths generally exhibited lower HDL cholesterol levels.
Conclusions:
- A significant inverse relationship exists between axial length and HDL cholesterol levels in children.
- This finding suggests a potential link between eye growth and lipid metabolism in pediatric populations.
- Further research is warranted to explore the clinical implications of this association.
Background:
To analyze the relationship between axial length and levels of high-density lipoprotein (HDL) cholesterol in children.
Methods:
A retrospective, hospital-based cross-sectional research with 69 right eyes from 69 children who underwent health examination by Zhejiang Provincial People's Hospital was carried out. The participants were split into three groups: Group A (axial length < = 23 mm), Group B (axial length 23-24 mm), and Group C (axial length > 24 mm). Demographic epidemiological information, blood biochemical parameters and ophthalmic characteristics including refractive status and ocular geometric parameters were obtained and analyzed.
Results:
69 right eyes from 69 patients (25 males and 44 females) with a median age of 10.00 years old (IQR: 8.00-11.00 years) were included in the study. Within Group A, there were a total of 17 individuals; Group B consisted of 22 individuals; Group C included 30 individuals. The mean axial length of three groups was 22.148(0.360), 23.503(0.342) and 24.770(0.556) mm, respectively (p < 0.0001). The mean HDL levels were significantly different in three groups are 1.824(0.307), 1.485(0.253) and 1.507 (0.265) mmol/L, respectively. By applying a Pearson Coefficient, we evaluated the association between axial length and HDL and discovered that there was a statistically significant (p = 0.00025) and adverse (R = -0.43) association between axial length and HDL.
Conclusions:
We concluded from our study that there was a significantly inverse relationship between axial length and the levels of HDL in children.
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