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Updated: Aug 2, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Approaches to the synthesis of heterocyclic C-nucleosides
E M Mukhin1, K V Savateev1, V L Rusinov1
1Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 ul. Mira, 620002 Ekaterinburg, Russian Federation.
Abstract:
This review is focused on the synthetic strategies to heterocyclic C-nucleosides and covers the literature from 2011 to 2021. The main attention is paid to the following three approaches: the direct C-C coupling of a carbohydrate moiety with a preformed aglycon unit, the construction of a (pseudo)sugar residue on a pre-formed aglycon, and the construction of an aglycon on a pre-formed (pseudo)sugar. In each Section, the literature data are categorized in terms of the size of aglycon from simple to complex, the advantages and drawbacks of the reviewed approaches are discussed.
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