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Systemic vasculitis: one year in review 2023

Michele Moretti1, Elena Treppo2, Sara Monti3

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Clinical and Experimental Rheumatology
|April 19, 2023
PubMed

Insights

Systemic vasculitis involves chronic blood vessel inflammation. This review covers recent COVID-19 impacts, new treatments, and precision medicine approaches for small- and large-vessel vasculitis.

Area of Science:

  • Rheumatology and Immunology
  • Internal Medicine
  • Vascular Biology

Background:

  • Systemic vasculitides are chronic inflammatory diseases of blood vessels.
  • These conditions can lead to significant tissue damage and organ failure.
  • The COVID-19 pandemic has influenced vasculitis epidemiology and patient management.

Purpose of the Study:

  • To critically review recent literature on systemic vasculitis.
  • To focus on advancements in pathophysiology, diagnosis, and treatment.
  • To highlight the role of precision medicine in managing small- and large-vessel vasculitis.

Main Methods:

  • Comprehensive literature search of recent publications.
  • Critical analysis of studies on vasculitis pathophysiology and clinical aspects.
  • Review of emerging diagnostic tools and therapeutic strategies.

Main Results:

  • New insights into the pathogenesis of systemic vasculitis.
  • Identification of potential novel therapeutic targets.
  • Evaluation of newer glucocorticoid-sparing treatments with improved safety profiles.
  • Impact of COVID-19 on vasculitis patient care and disease patterns.

Conclusions:

  • Recent advancements offer improved understanding and management of systemic vasculitis.
  • Precision medicine holds promise for tailored treatment strategies.
  • Continued research is essential for optimizing patient outcomes in vasculitis.

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