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Novel polyketide from Fusarium verticillioide G102 as NPC1L1 inhibitors
Yuhan Zhang1, Wenjing Liu2, Gang Li1
1Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.
Natural Product Research
|April 19, 2023
Abstract:
One novel polyketide, fusaritide A (1), was isolated from a marine fish-derived halotolerant fungal strain Fusarium verticillioide G102. The structure was determined through extensive spectroscopic analysis and high-resolution electrospray ionization mass spectrometry. Fusaritide A (1) with unprecedented structure reduced cholesterol uptake by inhibiting Niemann-Pick C1-Like 1 (NPC1L1).

