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Rational Discourse on Virology and Pandemics.

David Bahry1

  • 1Department of Biology, Carleton University, Ottawa, Ontario, Canada.

Mbio
|April 19, 2023
PubMed
Summary

The origin of SARS-CoV-2 remains unknown. Prematurely dismissing a potential lab origin erodes public trust, and gain-of-function research risks outweigh its benefits.

Area of Science:

  • Virology
  • Scientific Discourse

Background:

  • A recent "call for rational discourse" on SARS-CoV-2 origin and gain-of-function (GOF) research was published by 156 virologists in ASM journals.
  • The discourse addressed critical topics including the SARS-CoV-2 virus origin and the implications of GOF research.

Purpose of the Study:

  • To respond to the call for rational discourse on SARS-CoV-2.
  • To argue that the origin of SARS-CoV-2 is currently unknown.
  • To assert that downplaying a potential lab origin and subsequent denial undermines public trust in science.

Main Methods:

  • This work is a response and argument, not based on new experimental data.
  • It analyzes the implications of scientific discourse and public trust related to SARS-CoV-2 origins.
  • It critically evaluates the benefits versus risks of gain-of-function research.
Keywords:
COVID-19SARS-CoV-2gain of functionlaboratory leakpublic trust in sciencezoonosis

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Main Results:

  • The origin of the SARS-CoV-2 virus is not definitively known.
  • The premature dismissal of a laboratory origin for SARS-CoV-2 has damaged public trust in science.
  • The perceived benefits of gain-of-function research of concern are overstated compared to their risks.

Conclusions:

  • Continued open and rational discourse is essential for scientific integrity.
  • Acknowledging the unknown origin of SARS-CoV-2 is crucial for maintaining public trust.
  • A more cautious approach to gain-of-function research is warranted due to its inherent risks.