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Increased lipid transfer activities in hyperlipidemic rabbit plasma.

Y S Son, D B Zilversmit

    Arteriosclerosis (Dallas, Tex.)
    |May 1, 1986
    PubMed
    Summary

    Hypercholesterolemia in rabbits, but not rats, is linked to increased cholesteryl ester and triglyceride transfer activities. This suggests a mechanism related to high cholesterol levels influences these lipid transfer processes.

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    THE TURNOVER RATE OF PHOSPHOLIPIDS IN THE PLASMA OF THE DOG AS MEASURED WITH RADIOACTIVE PHOSPHORUS.

    The Journal of general physiology·2009

    Area of Science:

    • Lipid Metabolism
    • Cardiovascular Research
    • Biochemistry

    Background:

    • Hypercholesterolemia, characterized by elevated cholesterol levels, is a significant risk factor for cardiovascular disease.
    • Lipid transfer proteins play a crucial role in lipoprotein metabolism and cholesterol transport.

    Purpose of the Study:

    • To investigate the association between hypercholesterolemia and plasma cholesteryl ester and triglyceride transfer activities in animal models.
    • To compare these associations across different models of induced and genetic hypercholesterolemia in rabbits and rats.

    Main Methods:

    • Induction of hypercholesterolemia in rabbits using cholesterol-rich diets and a cholesterol-free semisynthetic diet.
    • Utilizing Watanabe heritable hyperlipidemic rabbits with a genetic LDL receptor defect.
    • Assessing plasma lipid transfer activities and cholesterol concentrations in rabbits and rats under various dietary and physiological conditions (fasting/refeeding).

    Main Results:

    • Plasma cholesteryl ester and triglyceride transfer activities increased significantly in cholesterol-fed and genetically hyperlipidemic rabbits.
    • Transfer activities showed a dose-dependent increase with plasma cholesterol levels in rabbits.
    • Hypercholesterolemia induced by diet in rats did not lead to increased transfer activities.
    • Fasting temporarily lowered transfer activities in rabbits, with refeeding restoring them.

    Conclusions:

    • Hypercholesterolemia in rabbits is positively associated with increased plasma cholesteryl ester and triglyceride transfer activities.
    • The findings suggest a mechanism linked to hypercholesterolemia, rather than hypercholesterolemia itself, drives these increased transfer activities in rabbits.
    • Species-specific responses indicate differences in lipid metabolism regulation between rabbits and rats.

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