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Updated: Aug 2, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Electrochemical deoxygenative arylation of aldehydes and ketones
Meng Li1, Yue Tian1, Kunhui Sun1
1Technical Institute of Fluorochemistry (TIF), State Key Laboratory of Materials-Oriented Chemical Engineering (MCE), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. tianlifang@njtech.edu.cn.
Abstract:
The construction of diaryl alkanes from aromatic aldehydes or ketones with electron-deficient arenes is achieved in the presence of trivalent phosphine under electrochemical conditions. Reductive coupling between electron-deficient arenes and the carbonyl groups of aldehydes or ketones occurs at the cathode to yield diaryl alcohols. At the anode, the trivalent phosphine reagent may undergo single-electron oxidation to generate its radical cation, which reacts with the diaryl alcohols to form dehydroxylated products.
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