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Updated: Aug 2, 2025

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
The need for good practice in the application of mechanistic constructs in hazard and risk assessment
M E Bette Meek1,2, Daniele Wikoff3
1McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Ontario K1G 5Z3, Canada.
Abstract:
A series of recent and proposed workshops address the interface between key characteristics and mechanistic pathway descriptions (adverse outcome pathways and mode of action) to identify commonalities and potential for complementary application. Informed by different communities, these constructs have collective potential to increase confidence to support the application of mechanistic data in hazard assessment. This forum article summarizes concepts, introduces evolving understanding, and invites future collaboration to contribute to better common understanding and development of good practice in the use of mechanistic data in hazard assessment.
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