Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hydrogel-based cellular drug delivery systems as living therapeutics: Micro/nanogel design, fabrication, and controlled release.

Journal of controlled release : official journal of the Controlled Release Society·2026

Same author

Adoptive T-cell therapies in the clinic.

Bioengineering & translational medicine·2026

Same author

In-the-Clinic series: A 10 year journey.

Bioengineering & translational medicine·2026

Same author

Safety, Distribution, and Pharmacokinetics of Biodegradable P(AAm-co-MAA) Nanogels Following Systemic Administration in Mice.

Journal of biomedical materials research. Part A·2026

Same author

Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution.

Nature ecology & evolution·2026

Same author

High Concentration Antibody Formulations Enabled via Thermostable Ionic Liquids.

Advanced materials (Deerfield Beach, Fla.)·2026

Same journal

Tau protein as a regulator of mitochondrial function and dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Epigenetic regulation of mesenchymal BMP signaling directs postnatal organ innervation.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Single-shot wide-field biochemical imaging at 1 kHz frame rate.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Morphogenesis and topological evolution of a frustrated nematic liquid crystal under confinement.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.

Proceedings of the National Academy of Sciences of the United States of America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 2, 2025

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

A backpack-based myeloid cell therapy for multiple sclerosis.

Neha Kapate^1,2,3, Michael Dunne^1,2, Ninad Kumbhojkar^1,2

¹John A. Paulson School of Engineering & Applied Sciences, Harvard University, Allston, MA 02134.

Proceedings of the National Academy of Sciences of the United States of America

|April 19, 2023

Summary

This summary is machine-generated.

Researchers developed novel "backpack" microparticles to reprogram myeloid cells into an anti-inflammatory state, effectively reducing disease severity in a multiple sclerosis mouse model and improving motor function.

Keywords:

CNS Immunoengineering macrophages myeloid phenotype

More Related Videos

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice

Published on: April 1, 2015

Related Experiment Videos

Last Updated: Aug 2, 2025

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice

Published on: April 1, 2015

Area of Science:

Immunology
Neuroscience
Biomaterials Science

Background:

Multiple sclerosis (MS) is an autoimmune disease with no cure, currently managed with immunosuppressants causing side effects.
Myeloid cell dysfunction is implicated in MS, yet their therapeutic potential remains largely unexplored.

Purpose of the Study:

To investigate a novel myeloid cell-based therapeutic strategy for MS using engineered microparticles.
To assess the efficacy of modulating myeloid cell phenotype for treating experimental autoimmune encephalomyelitis (EAE), an MS model.

Main Methods:

Developed monocyte-adhered microparticles ("backpacks") delivering interleukin-4 and dexamethasone to activate anti-inflammatory myeloid phenotypes.
Administered backpack-laden monocytes to EAE mice and evaluated their infiltration into the central nervous system (CNS).
Assessed the impact of backpack-monocytes on myeloid cell function, immune cell populations (T helper 1/17), cytokine levels, and motor function.

Main Results:

Backpack-laden monocytes successfully infiltrated the inflamed CNS and modulated both local and systemic immune responses.
Treated monocytes altered myeloid cell compartments within the CNS, impacting antigen presentation and reactive species production.
Significant reduction in systemic pro-inflammatory cytokines and modulation of T_H1/T_H17 populations were observed.
Therapeutic intervention led to improved motor function in EAE mice.

Conclusions:

Myeloid cells can be therapeutically reprogrammed using biomaterial-based "backpacks" to combat MS-like pathology.
This approach offers an antigen-free method to precisely tune cell phenotype in vivo, highlighting myeloid cells as a viable therapeutic target.