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Smoking cessation for peripheral arterial disease: systematic review protocol
Danielle Akemi Bergara Kuramoto1, Luiz Fernando Santetti Zanin1, Ronald Luiz Gomes Flumignan1
1- Universidade Federal de São Paulo, Disciplina de Cirurgia Vascular, Departamento de Cirurgia - São Paulo - SP - Brasil.
Revista Do Colegio Brasileiro De Cirurgioes
|April 19, 2023
Summary
Smoking cessation interventions significantly impact peripheral arterial disease (PAD) outcomes. This systematic review assesses interventions versus control groups to improve PAD-related mortality, amputation rates, and quality of life (QoL).
Area of Science:
- Vascular Medicine
- Public Health
- Evidence-Based Medicine
Background:
- Smoking is the primary modifiable risk factor for peripheral arterial disease (PAD).
- Existing research often overlooks smoking as the central exposure variable in PAD studies.
Purpose of the Study:
- To systematically evaluate the effectiveness of smoking cessation interventions for peripheral arterial disease (PAD).
- To compare interventions against active comparators, placebo, or no intervention.
- To analyze the impact on key PAD-related outcomes.
Main Methods:
- Systematic review following the Cochrane Handbook for Systematic Reviews of Interventions.
- Inclusion of parallel/cluster-randomized controlled trials (RCTs), quasi-RCTs, and cohort studies.
- Comprehensive database searches (CENTRAL, MEDLINE, Embase, PsycINFO, LILACS, IBECS) and trial registries.
- Independent review by at least two researchers.
- GRADEpro GDT software for reporting pooled effect estimates and certainty of evidence.
Main Results:
- Pooled effect estimates will be reported for all-cause mortality, lower limb amputation, and adverse events.
- Assessment of impact on walking distance, clinical severity, and vessel/graft patency.
- Evaluation of changes in quality of life (QoL) associated with interventions.
Conclusions:
- The review will assess outcomes using the five GRADE considerations.
- Conclusions will be drawn regarding the certainty of the evidence for each outcome.
- This will inform clinical practice and future research on smoking cessation in PAD management.
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