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Updated: Aug 2, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

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Management and outcomes of obstructive sleep apnea in infants

Elliot Morse1, Nicola Pereira1, Katie Liu1

  • 1Weill Cornell Medicine, Department of Otolaryngology-Head and Neck Surgery, 1305 York Avenue, New York, NY, 10065, USA.

International Journal of Pediatric Otorhinolaryngology
|April 19, 2023
PubMed

Insights

Infant obstructive sleep apnea (OSA) often resolves, particularly in infants without airway or hypotonia issues. Surgical intervention did not impact OSA resolution rates in this study.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Neonatology

Background:

  • Obstructive sleep apnea (OSA) in infants presents unique clinical challenges.
  • Understanding OSA resolution is crucial for management and parental counseling.
  • Infant OSA is associated with prematurity, craniofacial abnormalities, and hypotonia.

Purpose of the Study:

  • To characterize clinical features of infant OSA.
  • To determine the resolution rate of OSA in infants.
  • To identify factors influencing OSA resolution in this population.

Main Methods:

  • Retrospective chart review of infants diagnosed with OSA before one year of age.
  • Data collection included comorbidities, airway evaluations, surgical history, and respiratory support.
  • OSA resolution defined by clinical assessment or polysomnography; statistical analysis using chi-squared tests.

Main Results:

  • A high resolution rate of 74% was observed in 83 infants studied.
  • Airway abnormalities (p=0.010) and hypotonia (p=0.014) were associated with lower OSA resolution rates.
  • Surgical intervention (p=0.98) and supraglottoplasty for laryngomalacia (p=1.00) did not significantly affect resolution.

Conclusions:

  • Infant OSA exhibits diverse comorbidities with a generally high resolution rate.
  • Factors like airway abnormalities and hypotonia negatively impact OSA resolution.
  • Further prospective studies are needed to fully understand infant OSA consequences and optimize treatment strategies.
Abstract

Keywords:
Apnea-hypopnea indexInfantLaryngomalaciaMicrognathiaObstructive sleep apneaPolysomnogram

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