Related Experiment Video

Updated: Aug 2, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Clinical Trial Design for Lipoprotein(a)-Lowering Therapies: JACC Focus Seminar 2/3

Waqas A Malick1, Sascha N Goonewardena2, Wolfgang Koenig3

  • 1The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Journal of the American College of Cardiology
|April 19, 2023
PubMed

Insights

Lipoprotein(a) [Lp(a)] contributes to residual cardiovascular risk. New therapies targeting Lp(a) show promise for reducing atherosclerotic cardiovascular disease (ASCVD) events.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Pharmacology

Background:

  • Lipoprotein(a) [Lp(a)] is a significant contributor to residual risk in patients with atherosclerotic cardiovascular disease (ASCVD).
  • Previous research with PCSK9 inhibitors suggests Lp(a) reduction correlates with cardiovascular event reduction.
  • Emerging targeted therapies offer new strategies for lowering Lp(a) and mitigating ASCVD risk.

Purpose of the Study:

  • To evaluate the potential of novel therapies to reduce Lp(a) levels.
  • To explore the impact of Lp(a) lowering on cardiovascular outcomes.
  • To address challenges in clinical trial design for Lp(a)-targeted treatments.

Main Methods:

  • Clinical trials are investigating antisense oligonucleotides (e.g., pelacarsen) and small-interfering RNA (siRNA) therapies (e.g., olpasiran).
  • The Lp(a)HORIZON trial is a Phase 3 outcome study assessing pelacarsen's effect on major cardiovascular events.
  • Ongoing Phase 3 trials are evaluating siRNA-based therapies like olpasiran.

Main Results:

  • Reductions in Lp(a) concentrations with certain therapies may predict event reduction.
  • Selective Lp(a)-lowering therapies are entering advanced clinical trials.
  • Further research is needed to confirm the efficacy of these novel approaches.

Conclusions:

  • Targeted therapies for Lp(a) hold promise for reducing ASCVD risk.
  • Successful clinical trials could lead to new treatment paradigms for cardiovascular disease.
  • Optimizing patient selection and trial design is crucial for advancing Lp(a)-lowering therapies.

Keywords:
Lp(a)Lp(a) clinical trialsolpasiranpelacarsen

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.3K

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
717
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
151
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
209