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3D-Printed Functional Hydrogel by DNA-Induced Biomineralization for Accelerated Diabetic Wound Healing
Nahyun Kim1,2, Hyun Lee1,2, Ginam Han1,2
1Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 20, 2023
Summary
Researchers developed advanced 3D-printed wound dressings using salmon DNA and biosilica. These innovative dressings accelerate healing for chronic diabetic wounds by reducing inflammation and promoting tissue repair.
Area of Science:
- Biomaterials Engineering
- Regenerative Medicine
- Nanotechnology
Background:
- Chronic diabetic wounds present significant healing challenges due to prolonged inflammation.
- Current wound dressings lack customization for varied wound shapes and depths.
- 3D-printing and AI offer potential for precise, versatile wound dressing fabrication.
Purpose of the Study:
- To develop functional 3D-printing inks for customized wound dressings.
- To utilize DNA and biosilica for enhanced wound healing properties.
- To leverage machine learning for optimized 3D printing of wound dressings.
Main Methods:
- Formulation of hydrogel inks with salmon DNA and DNA-induced biosilica.
- Machine learning-guided 3D printing of wound dressings.
- Characterization of porosity, absorption, mechanical properties, and biological activity.
Main Results:
- 3D-printed dressings exhibited optimal porosity, exudate absorption, and mechanical tunability.
- Incorporated DNA and biosilica demonstrated nanotherapeutic effects.
- Dressings enhanced reactive oxygen species scavenging, angiogenesis, and anti-inflammation.
Conclusions:
- Bioinspired 3D-printed hydrogels using DNA-induced biomineralization are effective for wound repair.
- These dressings show significant potential for accelerating both acute and diabetic wound healing.
- The developed platform offers a promising solution for clinical applications in chronic wound management.
