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Dose Delays, Dose Reductions, and Relative Total Dose Intensity in Patients With Advanced Cancer Who Exercised During
Karen Y Wonders1,2, Kathryn Schmitz3, Jay Harness2
1Wright State University, Dayton, OH, USA.
Integrative Cancer Therapies
|April 20, 2023
Summary
Patients with advanced cancer who exercised during chemotherapy experienced fewer treatment delays and dose reductions. Adherence to exercise programs improved chemotherapy delivery and outcomes in cancer patients.
Area of Science:
- Oncology
- Exercise Science
- Clinical Research
Background:
- Maintaining chemotherapy dose intensity is crucial for optimal cancer treatment outcomes.
- Chemotherapy-induced side effects often lead to reduced dose intensity.
- Exercise interventions can help manage chemotherapy-related symptoms.
Purpose of the Study:
- To analyze the impact of exercise training on chemotherapy dose intensity in patients with advanced cancer.
- To determine if exercise adherence influences the occurrence of chemotherapy dose delays and reductions.
Main Methods:
- Retrospective chart review of 184 patients (Stage IIIA-IV cancer) undergoing chemotherapy.
- Patients completed at least 12 weeks of supervised, individualized exercise (cardiovascular, resistance, flexibility).
- Relative Dose Intensity (RDI) was calculated, with <85% RDI defined as a clinically meaningful reduction.
Main Results:
- Over 50% of patients received less than 85% of the planned Relative Dose Intensity.
- High exercise adherence (above 84.3%) was associated with significantly fewer chemotherapy dose delays and reductions.
- These positive effects were statistically significant compared to sedentary populations (P < .05).
Conclusions:
- Exercise training is a viable strategy to improve chemotherapy adherence in advanced cancer patients.
- Higher exercise adherence may mitigate treatment interruptions, potentially improving therapeutic efficacy.
- Further research should explore exercise's role in optimizing cancer treatment delivery.
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