Uranyl nitrate as a recyclable homogeneous photocatalyst for selective cross-coupling of N-substituted amines and
Shuaipeng Lv1,2, Qiannan Li1,2, Ji-Wei Sang2
1Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine No. 1200, Cailun Road Shanghai 201203 China yzhang@shutcm.edu.cn dzhangy@hotmail.com.
Abstract:
A homogeneous photocatalytic recyclable system for the selective radical-radical cross-coupling of N-substituted amines and indoles has been established. This system could conduct in water or acetonitrile, featuring the reuse of uranyl nitrate as the recyclable photocatalyst via a simple extraction. With this mild strategy in hand, good to excellent yields of cross-coupling products could be achieved even under the irradiation of sunlight, including 26 natural product derivatives and 16 natural product inspired re-engineered compounds. A radical-radical cross-coupling mechanism was newly proposed based on experimental evidence and reported literature. This strategy has been also applied to a gram scale synthesis to demonstrate its practical utility.
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