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Telomere dysfunction in some pediatric congenital and growth-related diseases

Bo Zheng1, Jianhua Fu1

  • 1Department of Pediatrics, Sheng Jing Hospital of China Medical University, Shenyang, China.

Frontiers in Pediatrics
|April 20, 2023
PubMed

Insights

Telomere dysfunction is linked to aging diseases and pediatric conditions. This review explores telomere biology

Area of Science:

  • Genetics
  • Cell Biology
  • Pediatrics

Background:

  • Telomere attrition and dysfunction are implicated in aging-related diseases.
  • Emerging evidence suggests telomere dysfunction also impacts pediatric disease development and prognosis.

Purpose of the Study:

  • To systematically review the relationship between telomere biology and pediatric congenital and growth-related diseases.
  • To propose novel theoretical frameworks and therapeutic targets for these pediatric conditions.

Main Methods:

  • Systematic literature review.
  • Analysis of existing research on telomere biology in pediatric diseases.

Main Results:

  • Telomere dysfunction is associated with various pediatric congenital and growth-related diseases.
  • Understanding telomere dynamics offers insights into disease pathogenesis.

Conclusions:

  • Telomere biology is a critical factor in pediatric disease.
  • Targeting telomere pathways may provide new therapeutic strategies for children.

Keywords:
aginginfantspediatric diseasestelomerase (TERT)telomere

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