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Updated: Aug 2, 2025

Intracranial Injection of Adeno-associated Viral Vectors
Published on: November 17, 2010
Cerebral venous sinus thrombosis following ChAdOx1 nCoV-19 AstraZeneca COVID-19 vaccine
Shyam S Sharma1, Giosue Gulli2, Pankaj Sharma3,4
1Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Abstract:
A woman in her mid-twenties was admitted with headache, ultimately leading to a diagnosis of cerebral venous sinus thrombosis 10 days after receiving a first dose of the AstraZeneca ChAdOx1 nCoV-19 vaccine (Vaxzevria). We report this case from clinical investigations to outcomes and discuss the issues raised by it regarding the ChAdOx1 nCoV-19 vaccine.
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