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Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
Tien Nguyen1, Sergey Brodsky2, Natallia Maroz3,4
1Internal Medicine, Kettering Health Main Campus, Dayton, USA.
Abstract:
An 81-year-old woman was referred to nephrology for a follow-up on progressive chronic kidney disease. She has a past medical history of hypertension, T2DM, breast cancer, and secondary hyperparathyroidism related to renal disease. A renal biopsy showed patchy interstitial fibrosis and tubular atrophy with an increased number of IgG4-positive plasma cells. A diagnosis of IgG4-related kidney disease was made based on clinical presentation and pathology. The patient ultimately required the initiation of hemodialysis, despite the administration of steroids and rituximab.
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