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Transporter Associated with Antigen Processing 1 Gene Polymorphisms Increase the Susceptibility to Tuberculosis
Tianchang Lu1, Minyi Wang1,2, Nannan Liu1
1Department of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, 650118, People's Republic of China.
Pharmacogenomics and Personalized Medicine
|April 20, 2023
Summary
Genetic variations in the TAP1 gene, specifically rs41551515-T and a combination of rs1057141-T-rs1135216-C, are linked to increased tuberculosis susceptibility. Novel TAP1 alleles also show a significant association with TB risk.
Area of Science:
- Immunogenetics
- Infectious Diseases
- Molecular Biology
Background:
- Tuberculosis (TB) arises from host immune response and Mycobacterium infection interplay.
- The transporter associated with antigen processing (TAP) is crucial for Mycobacterium tuberculosis antigen processing and presentation.
Purpose of the Study:
- To investigate the association between TAP1 and TAP2 genes and tuberculosis susceptibility.
- To identify specific genetic variants within TAP genes that influence TB risk.
Main Methods:
- Genotyping of single nucleotide polymorphisms (SNPs) and alleles in TAP1 and TAP2 genes.
- Case-control study involving 449 TB patients and 435 healthy controls.
Main Results:
- The TAP1 variant rs41551515-T was significantly associated with TB and pulmonary TB (PTB) susceptibility.
- A combination of TAP1 variants (rs1057141-T-rs1135216-C) markedly increased TB susceptibility risk.
- A novel TAP1 allele (TAP1*unknown_3) was prevalent in TB patients and associated with increased TB risk.
- No significant association was found between the TAP2 gene and TB susceptibility.
Conclusions:
- Specific host genetic variants in TAP1, including rs41551515-T and the combined rs1057141-T-rs1135216-C, are critical factors in TB susceptibility.
- The novel TAP1*unknown_3 allele may play a significant role in the development of TB.
- TAP2 gene variants do not appear to be associated with TB susceptibility in this population.
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