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Biomaterial-Based bFGF Delivery for Nerve Repair.
Qinying Huang1,2, Bo Liu1,2, Wencan Wu1,2
1State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China.
Oxidative Medicine and Cellular Longevity
|April 20, 2023
Summary
Biomaterials enhance the stability of basic fibroblast growth factor (bFGF) for improved nerve repair. This review explores biomaterial applications for sustained bFGF delivery to treat nervous system diseases.
Area of Science:
- Neuroscience
- Biomaterials Science
- Regenerative Medicine
Background:
- Nervous system diseases impose significant burdens due to high costs and poor prognoses.
- Basic fibroblast growth factor (bFGF) is vital for tissue homeostasis, regulating cell proliferation, differentiation, and repair.
- Improving bFGF stability is crucial for enhancing treatment efficacy in various diseases.
Purpose of the Study:
- To review biomaterials used for basic fibroblast growth factor (bFGF) delivery for nerve repair.
- To elucidate the function of delivered bFGF within the nervous system.
- To provide guidance for future research on nerve injury using bFGF.
Main Methods:
- Literature review of studies employing biomaterials for bFGF delivery.
- Analysis of bFGF's role in neural tissue regeneration.
- Synthesis of information on biomaterial-based sustained release systems.
Main Results:
- Biomaterials offer a biocompatible approach to stabilize and deliver bFGF.
- Sustained local delivery of bFGF via biomaterials promotes nerve repair.
- Various biomaterial types are effective for bFGF loading and controlled release.
Conclusions:
- Biomaterial-mediated bFGF delivery is a promising strategy for treating nerve injuries.
- Further research is needed to optimize biomaterial-bFGF systems for clinical application.
- This review offers a framework for future studies in bFGF-based nerve regeneration.
