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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

49
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
49
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

59
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
59
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

47
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
47
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

48
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
48
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

30
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
30
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

45
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Related Experiment Video

Updated: Aug 2, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
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Published on: April 25, 2025

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Long COVID: Is there a kidney link?

Raymond E Garrett1, Carlos H Palacio2, David Bar-Or1,2

  • 1Swedish Medical Center, Trauma Research Dept., Englewood, CO, United States.

Frontiers in Medicine
|April 20, 2023
PubMed
Summary

Long COVID may stem from metabolic issues affecting kidney function. This study explores renal-metabolic pathways, including creatine phosphate and tryptophan metabolism, for better diagnostics and treatments.

Keywords:
SARS-CoV-2 (COVID 19)arginine-glycine-amidinotransferase (AGAT)creatine phosphate (CP)glomerular reclamationkynurenine (KYN)long COVIDproximal tubule cell

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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Area of Science:

  • Biochemistry
  • Nephrology
  • Metabolic pathways

Background:

  • Long COVID symptoms may be linked to metabolic dysregulation.
  • Renal-metabolic pathways are crucial but understudied in Long COVID.
  • Altered bioenergetics and amino acid metabolism are implicated.

Purpose of the Study:

  • To investigate the role of renal-metabolic regulation in Long COVID.
  • To propose biochemical mechanisms of kidney involvement in Long COVID.
  • To identify potential targets for improved diagnostics and therapy.

Main Methods:

  • Biochemical analysis of renal tubular injury.
  • Exploration of creatine phosphate metabolism.
  • Investigation of tryptophan metabolism in proximal tubule cells.

Main Results:

  • Three potential mechanisms linking renal-metabolic dysfunction to Long COVID symptoms are proposed.
  • Creatine phosphate metabolism alterations may contribute.
  • COVID-specific proximal tubule cell injury via tryptophan metabolism is hypothesized.

Conclusions:

  • Renal-metabolic pathways, particularly involving creatine phosphate and tryptophan, are critical in Long COVID.
  • Understanding these mechanisms can lead to novel diagnostic and therapeutic strategies.
  • Targeting renal-metabolic dysfunction offers a promising avenue for Long COVID treatment.