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Multiple colorectal adenomas in Lynch syndrome
Ayushi Jain1, Maryam Alimirah2, Heather Hampel3
1Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Frontiers in Oncology
|April 20, 2023
Summary
Multiple colorectal adenomas (MCRA) are not uncommon in Lynch syndrome patients and are linked to a higher risk of advanced neoplasia. Colonoscopy intervals may need adjustment based on polyp burden in Lynch syndrome.
Area of Science:
- Gastroenterology
- Oncology
- Genetics
Background:
- Lynch syndrome is not typically associated with a high adenoma burden.
- Increasing adenoma detection rates may lead to higher cumulative adenoma counts in Lynch syndrome patients.
Purpose of the Study:
- To determine the prevalence of multiple colorectal adenomas (MCRA) in Lynch syndrome.
- To evaluate the clinical impact of MCRA in Lynch syndrome.
Main Methods:
- Retrospective review of Lynch syndrome patients.
- Assessment for MCRA, defined as 10 or more cumulative adenomas.
Main Results:
- 14 out of 222 Lynch syndrome patients (6.3%) met MCRA criteria.
- Patients with MCRA had a significantly increased incidence of advanced neoplasia (OR 10).
Conclusions:
- MCRA is a notable finding in Lynch syndrome.
- MCRA is associated with a substantially higher likelihood of advanced colon neoplasia.
- Colonoscopy surveillance intervals may require tailoring based on polyp burden in Lynch syndrome.
