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Nanosensitive optical coherence tomography for detecting structural changes in stem cells.

Anand Arangath1, Niamh Duffy2, Sergey Alexandrov1

  • 1Tissue Optics and Microcirculation Imaging Facility, Physics, School of Natural Sciences, University of Galway, Galway, Ireland.

Biomedical Optics Express
|April 20, 2023
PubMed
Summary
This summary is machine-generated.

Nanosensitive optical coherence tomography (nsOCT) can image mesenchymal stromal cells (MSCs) labeled with gold nanostars. This technique detects nanoscale changes, aiding the understanding of cell therapy mechanisms and safety.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Mesenchymal stromal cells (MSCs) show therapeutic potential for various diseases.
  • Tracking MSCs in vivo is crucial for understanding their mechanism of action and safety.
  • Existing imaging modalities lack the sensitivity for nanoscale detection of cell alterations.

Purpose of the Study:

  • To evaluate nanosensitive optical coherence tomography (nsOCT) for imaging MSC pellets.
  • To assess the effect of gold nanostar labeling on MSC pellet structure using nsOCT.
  • To enhance the understanding of MSC pellet chondrogenesis models.

Main Methods:

  • MSCs were labeled with varying concentrations of dual plasmonic gold nanostars.
  • Nanosensitive optical coherence tomography (nsOCT) was used to image the labeled MSC pellets.
  • Quantitative analysis of structural changes, including mean spatial period, was performed.

Main Results:

  • nsOCT successfully imaged MSC pellets labeled with gold nanostars.
  • Increasing gold nanostar concentrations correlated with an increased mean spatial period of MSC pellets.
  • Enhanced analysis provided deeper insights into the MSC pellet chondrogenesis model.

Conclusions:

  • nsOCT is a sensitive tool for detecting nanoscale structural alterations in labeled MSCs.
  • This technique offers potential for quantitative and qualitative monitoring of cell therapies.
  • nsOCT may provide crucial functional information for cell therapy development and safety assessment.