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Value of monocyte distribution width for predicting severe cholecystitis: a retrospective cohort study
Chih-Hao Kao1,2, Yen-Hung Liu1,3,2, Wei-Kung Chen1,2
1Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.
Clinical Chemistry and Laboratory Medicine
|April 20, 2023
Summary
Monocyte distribution width (MDW) can predict severe cholecystitis and prolonged hospital stays. This simple blood test offers early insights into gallbladder inflammation severity, aiding clinical decisions.
Area of Science:
- Medical diagnostics
- Inflammatory markers
Background:
- Acute cholecystitis is gallbladder inflammation.
- Tokyo Guidelines 2018 (TG18) assess severity but require many parameters.
- Monocyte distribution width (MDW) is an early sepsis detection marker.
Purpose of the Study:
- Investigate the correlation between MDW and cholecystitis severity.
- Evaluate MDW as a predictor for severe cholecystitis and prolonged hospital stay.
Main Methods:
- Retrospective study of 331 cholecystitis patients (Nov 2020 - Aug 2021).
- Primary outcome: severe cholecystitis (ICU admission or mortality).
- Secondary outcomes: length of stay, ICU stay, TG18 grade.
Main Results:
- Average MDW for TG18 grades 1, 2, and 3 were 20.21, 20.34, and 25.77.
- Severe cholecystitis patients had an average MDW of 25.42.
- MDW ≥ 21.6 predicted higher risk of severe cholecystitis (OR=4.94, p=0.003) and prolonged hospital stay.
Conclusions:
- MDW is a reliable indicator for severe cholecystitis.
- MDW ≥ 21.6 is associated with increased risk and prolonged hospital stay.
- MDW testing can provide simple, early information for predicting cholecystitis severity.
