Related Experiment Video
Updated: Aug 2, 2025
07:15
Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
59.5K
Intranasal Insulin for the Treatment of Persistent Post-COVID-19 Olfactory Dysfunction
Giancarlo B Cherobin1, Roberto E S Guimarães1, Márcia C de Paula Gomes2
1Department of Ophthalmology and Otolaryngology, Medical School of Federal University of Minas Gerais, Belo Horizonte, Brazil.
Summary
Intranasal insulin rapidly improved sense of smell in patients with persistent post-COVID-19 olfactory dysfunction. This treatment using neutral protamine Hagedorn (NPH) insulin appears safe and effective for olfactory dysfunction.
Area of Science:
- Otolaryngology
- Endocrinology
- Infectious Diseases
Background:
- Persistent olfactory dysfunction is a common sequela of COVID-19.
- Standard therapies like corticosteroids often fail to restore the sense of smell.
Purpose of the Study:
- To investigate intranasal insulin as a potential treatment for post-COVID-19 olfactory dysfunction.
- To assess the safety and efficacy of neutral protamine Hagedorn (NPH) insulin administered intranasally.
Main Methods:
- A prospective interventional cohort study involving 16 volunteers with persistent olfactory dysfunction post-COVID-19.
- NPH insulin (40 IU per nostril) was administered via gelatin sponge twice weekly for one month.
- Olfactory function was evaluated using the Chemosensory Clinical Research Center test of olfaction (COT) before and after treatment.
Main Results:
- Significant improvements were observed in qualitative (1.53 points), quantitative (2.00 points), and global (2.01 points) COT scores.
- P-values for all improvements were < .0002, indicating high statistical significance.
- A mean decrease of 10.4 mg/dL in blood glucose levels was noted post-treatment.
Conclusions:
- Intranasal NPH insulin administration demonstrates rapid efficacy in improving the sense of smell in patients with post-COVID-19 olfactory dysfunction.
- The treatment was found to be safe and well-tolerated by participants.
- Intranasal insulin presents a promising therapeutic option for recalcitrant olfactory deficits following SARS-CoV-2 infection.
More Related Videos
04:49Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
521
08:33Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
Published on: December 4, 2014
9.8K
Related Concept Videos
01:03Olfactory Receptors: Location and Structure
9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
01:26COPD: Management Using Bronchodilators and Corticosteroids
257
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
257
01:24Nose and Nasal Cavity
3.2K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
3.2K
01:29Administering Oxygen by Nasal Cannula
773
Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
773
01:16Drugs Used in Upper Respiratory Disorders: Overview
307
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
307
01:23Inhaled Medications
331
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
331