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Updated: Aug 2, 2025
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
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Imaging cortical lesions in multiple sclerosis
Caterina Mainero1,2, Constantina A Treaba1,2, Elena Barbuti1,3
1A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital.
Current Opinion in Neurology
|April 20, 2023
Summary
Cortical lesions in multiple sclerosis (MS) are key indicators of disease progression. Advanced MRI techniques improve detection and understanding of these lesions, aiding diagnosis and treatment strategies.
Area of Science:
- Neuroimaging
- Pathology
- Multiple Sclerosis Research
Background:
- Cortical lesions are integral to multiple sclerosis (MS) pathology, present from early stages, and drive disease progression.
- Understanding cortical lesions is crucial for MS diagnosis, prognosis, and therapeutic development.
Approach:
- This review discusses current in vivo imaging methodologies for detecting cortical lesions.
- Focuses on how advanced imaging, particularly ultra-high field MRI, enhances lesion detection and reveals pathogenetic insights.
Key Points:
- Cortical lesions, though sometimes missed by MRI, hold significant clinical relevance for MS diagnosis and predicting progression.
- Ultra-high field MRI improves detection rates and offers new insights into lesion development, evolution, and associated pathology.
- Cortical lesion assessment shows potential as a clinical trial outcome measure.
Conclusions:
- Despite imaging limitations, evaluating cortical lesions is vital for unraveling MS pathogenesis.
- Improved imaging of cortical lesions is essential for advancing patient management and therapeutic strategies in multiple sclerosis.
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