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Published on: August 16, 2024
Single-cell multi-omics sequencing and its application in tumor heterogeneity
Yuqing Sun1, Zhiyu Liu1, Yue Fu1
1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, People's Republic of China.
Single-cell multi-omics sequencing integrates genomics, transcriptomics, epigenomics, and proteomics for deep cellular insights. These advanced technologies are crucial for understanding complex diseases like cancer and advancing precision medicine.
Area of Science:
- Biotechnology
- Genomics
- Molecular Biology
Background:
- Single-cell sequencing technologies offer high-resolution analysis of DNA, RNA, and proteins.
- Advancements enable parallel multi-omics profiling from individual cells, revealing biological states and mechanisms.
- Reduced costs and improved throughput drive broader adoption.
Conclusions:
- Single-cell multi-omics is a powerful tool for understanding cellular complexity.
- Ongoing technological development promises enhanced capabilities for research and clinical use.
- This approach holds significant potential for advancing precision medicine and disease diagnostics.
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