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Cancer Protective Role of Selected Dietary Polyphenols via Modulating Keap1/Nrf2/ARE and Interconnected Signaling

Md Arman Islam1, Maisha Maliha Medha1, Akhlak Un Nahar1

  • 1Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.

Nutrition and Cancer
|April 20, 2023
PubMed

Insights

Dietary polyphenols may protect against cancer by activating the Keap1/Nrf2/ARE pathway. Further in vivo and clinical studies are needed to confirm these cancer-protective effects in humans.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The Keap1/Nrf2/ARE pathway is crucial for cellular defense against oxidative stress and plays a role in cancer development.
  • Dietary polyphenols are investigated for their potential cancer-protective properties.

Approach:

  • A comprehensive literature search was conducted across Google Scholar, PubMed, and Science Direct.
  • The review focused on 21 dietary polyphenols and their modulation of the Keap1/Nrf2/ARE pathway and related signaling cascades.
  • Information on anti-inflammatory and cytoprotective effects was also collected.

Key Points:

  • Most studies indicate a cancer-protective role for selected polyphenols, primarily in vitro.
  • The Keap1/Nrf2/ARE pathway, along with MAPK/ERK1/2, PI3K/Akt, PKD, JNKs, AMPK, and NF-κB, are key targets.
  • Limited in vivo and clinical trial data exist for these polyphenols.

Conclusions:

  • Further in vivo research is recommended for methyleugenol, carnosol, and catechin.
  • Clinical trials are necessary to confirm the impact of dietary polyphenol consumption on human cancer incidence and progression.

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