Related Experiment Video

Updated: Aug 2, 2025

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

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Patent landscape highlighting double-edged scaffold of a WNT5A-agonizing peptide, Foxy5

Vikas Yadav1, Rubina Islam2, Hardeep Singh Tuli3

  • 1Interdisciplinary Cluster for Applied Genoproteomics (GIGA), B34 Sart-Tilman, University of Liege (ULiege), Liege, 4000, Belgium.

Pharmaceutical Patent Analyst
|April 20, 2023
PubMed

Insights

The WNT signaling pathway peptide Foxy5 shows promise in preventing cancer metastasis and relapse by targeting cancer stem cells. It demonstrates anti-cancer efficacy with a non-toxic profile, alone or with chemotherapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Aberrant WNT signaling pathway expression is linked to cancer progression and recurrence.
  • WNT-targetable small molecules face challenges in clinical translation.
  • WNT5A-mimicking peptide Foxy5 shows efficacy in impairing metastasis in cancers with low WNT5A expression.

Purpose of the Study:

  • To evaluate the efficacy of Foxy5 in preventing cancer relapse and metastasis.
  • To investigate the anti-stemness activity of Foxy5.
  • To assess the safety and synergistic potential of Foxy5 with standard chemotherapy.

Main Methods:

  • Utilized a mice xenograft model to demonstrate Foxy5's anti-stemness activity.
  • Assessed the suppression of colonic cancer stem cell markers.
  • Evaluated Foxy5's toxicity and synergy with chemotherapy.

Main Results:

  • Foxy5 demonstrated anti-stemness activity by suppressing cancer stem cell markers.
  • Foxy5 showed efficacy in impairing metastasis in relevant cancer models.
  • Foxy5 exhibited a non-toxic nature when administered alone or with chemotherapy.

Conclusions:

  • Foxy5 holds potential for cancer treatment and prevention of relapse.
  • Foxy5's anti-stemness and anti-metastatic properties make it a promising therapeutic candidate.
  • Foxy5's non-toxic profile supports its use in combination cancer therapy.
Keywords:
Foxy5WNT signalingdrug discoveryrecent patenttherapeutic peptides

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