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3D Inkjet-Bioprinted Lung-on-a-Chip.

Wookyeom Kim1, Yunji Lee1, Dayoon Kang2

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ACS Biomaterials Science & Engineering
|April 20, 2023
PubMed
Summary

Researchers developed a novel human alveolar lung-on-a-chip using inkjet bioprinting. This 3D model mimics lung tissue structure and function, offering a customizable platform for disease modeling and drug testing.

Keywords:
3D bioprintingalveolar barrierinkjet printinglung organoidorgan-on-a-chip

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Microfluidics

Background:

  • Physiologically relevant human lung tissue models are crucial for disease research and drug development.
  • Existing lung-on-a-chip models face limitations in replicating complex, multilayered tissue architectures and cellular arrangements.

Purpose of the Study:

  • To develop a physiologically relevant and customizable human alveolar lung-on-a-chip model.
  • To overcome fabrication limitations of conventional microfluidic lung models.

Main Methods:

  • Developed a modular organ-on-a-chip system using inkjet bioprinting to create a micron-thick, three-layered human lung tissue.
  • Layer-by-layer bioprinting of lung tissues within culture inserts, followed by modular implantation into a biochip for perfusion culture at the air-liquid interface.

Main Results:

  • Successfully created a 3D-structured, inkjet-bioprinted lung model with a three-layered architecture (tens of micrometers thick).
  • Achieved tight junctions in the epithelial layer, demonstrating critical alveolar barrier properties.
  • Confirmed upregulation of genes essential for alveolar functions in the bioprinted lung model.

Conclusions:

  • The developed lung-on-a-chip is a versatile, customizable platform for lung disease modeling and drug efficacy studies.
  • The modular design and bioprinting integration enable mass production and adaptation for various organ models.
  • This technology advances the development of organ-on-a-chip systems for personalized medicine.