Nanomaterial-based electrochemical sensors for detection of amino acids

Amino acids are the building blocks of proteins and muscle tissue. They also play a significant role in physiological processes related to energy, recovery, mood, muscle and brain function, fat burning and stimulating growth hormone or insulin secretion. Accurate determination of amino acids in biological fluids is necessary because any changes in their normal ranges in the body warn diseases like kidney disease, liver disease, type 2 diabetes and cancer. To date, many methods such as liquid chromatography, fluorescence mass spectrometry, etc. have been used for the determination of amino acids. Compared with the above techniques, electrochemical systems using modified electrodes offer a rapid, accurate, cheap, real-time analytical path through simple operations with high selectivity and sensitivity. Nanomaterials have found many interests to create smart electrochemical sensors in different application fields e.g. biomedical, environmental, and food analysis because of their exceptional properties. This review summarizes recent advances in the development of nanomaterial-based electrochemical sensors in 2017-2022 for the detection of amino acids in various matrices such as serum, urine, blood and pharmaceuticals.