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A zwitterionic solution for smart ionic liquids to evade cytotoxicity
Hsin-Heng Huang1, Jianbo Jia2, Luyao Ren3
1Department of Chemistry and Biochemistry and Advanced Institute of Manufacturing with High-tech Innovations, National Chung Cheng University, 621301, Taiwan, ROC.
Abstract:
By linking the cation and anion motifs of ionic liquids (ILs), zwitterionic liquids (ZILs) exhibit at least 146-2740 and 112-1550 folds less cytotoxicity in human gastric and colon cells than those of the structurally related ILs. Computer simulation shows that ZIL molecules hardly penetrate the cell membranes in contrast to ILs. These findings reveal a novel mechanism for ZILs to evade cytotoxicity, establishing a structure-based design principle for the next generation of sustainable ZILs.
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