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Mitochondrial replication, transcription, and function in obstructive sleep apnea.

Ching-Chi Lin1, Ying-Piao Wang2, Yi-Kun Sun1

  • 1Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.

Respiratory Physiology & Neurobiology
|April 20, 2023
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) elevates mitochondrial dysfunction markers in the upper airway. Uvulopalatopharyngoplasty improves these markers in responsive patients, indicating successful treatment of mitochondrial issues.

Keywords:
Obstructive sleep apnoeaexhaled breath condensatemitochondrial functionmitochondrial transcription factor Aperoxisome proliferator-coactivated receptor gamma coactivator 1-alphauvulopalatopharyngoplasty

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Area of Science:

  • Mitochondrial Biology
  • Sleep Medicine
  • Otolaryngology

Background:

  • Obstructive sleep apnea (OSA) is linked to systemic inflammation and cellular dysfunction.
  • Mitochondrial dynamics are increasingly recognized as critical in various pathologies.

Purpose of the Study:

  • To investigate mitochondrial replication, transcription, and function in the upper airways of OSA patients.
  • To evaluate the impact of uvulopalatopharyngoplasty on these mitochondrial parameters.

Main Methods:

  • Assessed TFAM and PGC-1α expression via immunohistochemistry, RT-PCR, and Western blotting in uvula specimens.
  • Measured mitochondrial to nuclear DNA (Mt/N) ratio in blood, EBC, and uvula using qPCR.
  • Quantified plasma and EBC TFAM and PGC-1α concentrations using ELISA.

Main Results:

  • OSA patients exhibited higher levels of TFAM, PGC-1α, and Mt/N ratio compared to controls.
  • Successful uvulopalatopharyngoplasty correlated with decreased TFAM, PGC-1α, and EBC Mt/N ratio.
  • Unresponsive patients maintained elevated levels of these mitochondrial markers.

Conclusions:

  • OSA is associated with increased mitochondrial replication, transcription signaling, and dysfunction in the upper airway.
  • Uvulopalatopharyngoplasty can restore mitochondrial homeostasis in OSA patients who respond to treatment.
  • Mitochondrial markers serve as indicators of OSA severity and treatment efficacy.