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Related Concept Videos

NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

746
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
746
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

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Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
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Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

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Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
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Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

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The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
769
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

256
Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
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2D NMR: Homonuclear Correlation Spectroscopy (COSY)01:06

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1.2K
Homonuclear correlation spectroscopy, or COSY, is a 2-dimensional NMR technique that provides information about coupled protons. Typically, the geminal and vicinal coupling are observed. For example, consider the COSY spectrum of ethyl acetate, where its 1D proton NMR spectrum is plotted along the vertical and horizontal axes with their corresponding chemical shift scale. Three spots on the diagonal corresponding to the three peaks in the 1D proton spectrum are called diagonal peaks. The COSY...
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Updated: Aug 2, 2025

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
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Automated optimization of spatial resolution for single-sided NMR.

Lyndi Kiple1, John Ballenger1, Kristina Keating2

  • 1Department of Chemistry, William & Mary, Integrated Science Center, Williamsburg, Virginia, USA.

Magnetic Resonance in Chemistry : MRC
|April 20, 2023
PubMed
Summary

An algorithmic approach precisely positions planar samples for single-sided Nuclear Magnetic Resonance (NMR) measurements. This method enhances spatial resolution, enabling detailed analysis of material properties.

Keywords:
automationinterfacesrelaxometrysingle-sided NMRspatial resolution

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Physics

Background:

  • Single-sided NMR instruments use strong magnetic field gradients for non-destructive material analysis.
  • High spatial resolution in planar sample measurements requires precise coplanarity with the magnet's sensitive region.

Purpose of the Study:

  • To develop an algorithmic method for accurate coplanar positioning of planar samples in single-sided NMR.
  • To improve spatial resolution and material property analysis using single-sided NMR.

Main Methods:

  • An adjustable stage with three degrees of freedom was employed for sample positioning.
  • A quadtree algorithm was utilized to find the optimal coplanar position for samples.
  • Resolution values were reported for position optimization, acquisition, and final spatial resolution.

Main Results:

  • The algorithmic positioning process demonstrated effectiveness across samples with diverse relaxation behaviors.
  • Optimized positioning achieved sufficient spatial resolution to differentiate physical regions in layered samples.
  • The method successfully distinguished sample regions based on varying relaxation properties.

Conclusions:

  • The developed algorithmic positioning process enhances spatial resolution in single-sided NMR measurements.
  • This technique is applicable to planar samples in both research and industrial settings.
  • Accurate sample positioning is crucial for detailed material characterization using single-sided NMR.