Pathogenetic Mechanisms of Mental Disorders: Endogenous Intoxication

Area of Science:

• Neuroscience
• Biochemistry
• Psychiatry

Background:

• Endogenous intoxication is increasingly recognized in the pathophysiology of mental disorders.
• This condition involves the accumulation of toxic substances within the body, impacting brain function.
• Key biochemical markers are associated with its development and progression.

Purpose of the Study:

• To review the syndrome of endogenous intoxication in patients with mental disorders.
• To elucidate the contributing factors and pathogenetic mechanisms.
• To discuss potential treatment approaches.

Main Methods:

• Literature review of studies on endogenous intoxication and mental disorders.
• Analysis of biochemical markers including oxidative stress and specific molecules.
• Examination of neurotrophic factors and enzyme activity.

Main Results:

• Oxidative stress and middle-mass endotoxic molecules are significant contributors.
• Impaired functional properties of serum albumin and albumin thiol groups play a role.
• Altered levels of neurotrophic factors and enzymes like monoamine oxidase are implicated.

Conclusions:

• Endogenous intoxication is a complex syndrome contributing to mental disorders.
• Targeting oxidative stress and specific molecular pathways may offer therapeutic benefits.
• Further research into treatment strategies is warranted.