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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

245
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
245
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

322
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
322
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

179
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
179
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

109
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
109
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

324
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
324
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

186
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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The appendix and ulcerative colitis - an unsolved connection.

Manasi Agrawal1,2, Kristine H Allin3,4, Saurabh Mehandru5,6

  • 1The Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. manasi.agrawal@mountsinai.org.

Nature Reviews. Gastroenterology & Hepatology
|April 20, 2023
PubMed
Summary
This summary is machine-generated.

The appendix may influence ulcerative colitis development and outcomes. Appendectomy (appendix removal) shows protective effects in some studies but requires further research for clinical relevance.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiome Research

Background:

  • The appendix's role in ulcerative colitis (UC) pathogenesis is debated.
  • Its immunological functions and microbiome interactions are key areas of investigation.

Purpose of the Study:

  • To explore the appendix's biological functions (immunology, microbiome).
  • To review evidence linking the appendix to ulcerative colitis development and outcomes.

Main Methods:

  • Review of experimental models and human observational studies.
  • Analysis of appendectomy's impact on UC incidence, disease course, and colectomy risk.

Main Results:

  • Experimental models show inflamed appendix removal prevents colitis.
  • Appendectomy is associated with protection against UC in human studies.
  • Pre-diagnosis appendectomy may affect UC outcomes, potentially reducing colectomy risk but possibly increasing colorectal cancer risk.

Conclusions:

  • Evidence suggests a link between the appendix and ulcerative colitis.
  • Appendectomy's role in UC treatment and prevention requires further investigation.
  • Clinical trials are ongoing to clarify the appendix's relevance in UC pathogenesis and management.